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Title of Journal: J Biol Inorg Chem

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Abbravation: JBIC Journal of Biological Inorganic Chemistry

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Springer Berlin Heidelberg

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DOI

10.1016/0019-2791(76)90383-9

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1432-1327

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Synthesis and crystal structures of novel copperI

Authors: Duygu İnci Rahmiye Aydın Özgür Vatan Tuba Sevgi Dilek Yılmaz Yunus Zorlu Yusuf Yerli Bünyemin Çoşut Elif Demirkan Nilüfer Çinkılıç
Publish Date: 2016/11/10
Volume: 22, Issue: 1, Pages: 61-85
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Abstract

New copperII complexes—dimericCunphenglyH2O+ 1 and CudmphenglyNO3H2O 2 nphen = 5nitro110phenanthroline dmphen = 47dimethyl110phenanthroline and gly = glycine—have been synthesized and characterized by CHN analysis singlecrystal Xray diffraction techniques FTIR EPR spectroscopy and cyclic voltammetry The CTDNAbinding properties of these complexes have been investigated by thermal denaturation measurements and both absorption and emission spectroscopy The DNA cleavage activity of these complexes has been studied on supercoiled pUC19 plasmid DNA by gel electrophoresis experiments in the absence and presence of H2O2 Furthermore the interaction of these complexes with bovine serum albumin BSA has been investigated using absorption and emission spectroscopy The thermodynamic parameters freeenergy change ΔG enthalpy change ΔH and entropy change ΔS for BSA + complexes 1 and 2 systems have been calculated by the van’t Hoff equation at three different temperatures 2932 3032 and 3102 K The distance between the BSA and these complexes has been determined using fluorescence resonance energy transfer FRET Conformational changes of BSA have been observed using the synchronous fluorescence technique In addition in vitro cytotoxicities of these complexes on tumor cell lines Caco2 A549 and MCF7 and healthy cells BEAS2B have been examined The antimicrobial activity of the complexes has also been tested on certain bacteria cells The effect of mono and dimeric in the above complexes is presented and discussedWe thank the Research Fund of Uludag University for the financial support given to the research projects Project Numbers OUAP F2015/14 and KUAPF2012/76 and the Scientific and Technological Research Council of Turkey TUBITAK for Domestic PhD Scholarship intended for Priority Areas of the first author Code 2211C This study is a part of doctoral thesis in progress of the first author at the Graduate School of Natural and Applied Sciences of Uludag University

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