Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: J Biol Inorg Chem

Search In Journal Title:

Abbravation: JBIC Journal of Biological Inorganic Chemistry

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

DOI

10.1016/0042-6822(91)90910-4

Search In DOI:

ISSN

1432-1327

Search In ISSN:
Search In Title Of Papers:

New vanadiumbased magnetic resonance imaging prob

Authors: Devkumar Mustafi Bo Peng Sean Foxley Marvin W Makinen Gregory S Karczmar Marta Zamora John Ejnik Heather Martin
Publish Date: 2009/07/02
Volume: 14, Issue: 8, Pages: 1187-
PDF Link

Abstract

We have developed a magnetic resonance imaging MRI method for improved detection of cancer with a new class of cancerspecific contrast agents containing vanadyl VO2+chelated organic ligands specifically bisacetylacetonatooxovanadiumIV VOacac2 Vanadyl compounds have been found to accumulate within cells where they interact with intracellular glycolytic enzymes Aggressive cancers are metabolically active and highly glycolytic an MRI contrast agent that enters cells with high glycolytic activity could provide highresolution functional images of tumor boundaries and internal structure which cannot be achieved by conventional contrast agents The present work demonstrates properties of VOacac2 that may give it excellent specificity for cancer detection A high dose of VOacac2 did not cause any acute or shortterm adverse reactions in murine subjects Calorimetry and spectrofluorometric methods demonstrate that VOacac2 is a blood pool agent that binds to serum albumin with a dissociation constant K d ~ 25 ± 07 × 10−7 M and a binding stoichiometry n = 103 ± 004 Owing to its prolonged blood halflife and selective leakage from hyperpermeable tumor vasculature a low dose of VOacac2 015 mmol/kg selectively enhanced in vivo magnetic resonance images of tumors providing highresolution images of their interior structure The kinetics of uptake and washout are consistent with the hypothesis that VOacac2 preferentially accumulates in cancer cells Although VOacac2 has a lower relaxivity than gadoliniumbased MRI contrast agents its specificity for highly glycolytic cells may lead to an innovative approach to cancer detection since it has the potential to produce MRI contrast agents that are nontoxic and highly sensitive to cancer metabolism


Keywords:

References


.
Search In Abstract Of Papers:
Other Papers In This Journal:

  1. The Fox1 ferroxidase of Chlamydomonas reinhardtii : a new multicopper oxidase structural paradigm
  2. Impaired hydrolysis of cisplatin derivatives to aquated species prevents energy-dependent uptake in GLC4 cells resistant to cisplatin
  3. Folding of the prion peptide GGGTHSQW around the copper(II) ion: identifying the oxygen donor ligand at neutral pH and probing the proximity of the tryptophan residue to the copper ion
  4. Rates of intercalator-driven platination of DNA determined by a restriction enzyme cleavage inhibition assay
  5. Rates of intercalator-driven platination of DNA determined by a restriction enzyme cleavage inhibition assay
  6. Effect of complex formation between Zn 2+ ions and the anticancer drug mithramycin upon enzymatic activity of zinc(II)-dependent alcohol dehydrogenase
  7. DNA targeting and cleavage by an engineered metalloprotein dimer
  8. Cobalt hexaamine mediated electrocatalytic voltammetry of dimethyl sulfoxide reductase: driving force effects on catalysis
  9. Ciliate metallothioneins: unique microbial eukaryotic heavy-metal-binder molecules
  10. Structural and thermodynamical properties of Cu II amyloid- β 16/28 complexes associated with Alzheimer’s disease
  11. Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals
  12. The role of axial ligands for the structure and function of chlorophylls
  13. Synthesis and structural characterization of soluble neuromelanin analogs provides important clues to its biosynthesis
  14. Synthesis and crystal structures of novel copper(II) complexes with glycine and substituted phenanthrolines: reactivity towards DNA/BSA and in vitro cytotoxic and antimicrobial evaluation
  15. Enantiopure copper(II) complex of natural product rosin derivative: DNA binding, DNA cleavage and cytotoxicity
  16. Human copper transporter Ctr1 is functional in Drosophila , revealing a high degree of conservation between mammals and insects
  17. A spectroscopic and voltammetric study of the pH-dependent Cu(II) coordination to the peptide GGGTH: relevance to the fifth Cu(II) site in the prion protein
  18. Kinetic and structural studies on roles of the serine ligand and a strictly conserved tyrosine residue in nitrile hydratase
  19. A realistic in silico model for structure/function studies of molybdenum–copper CO dehydrogenase
  20. Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aβ amyloid aggregates
  21. A systematic investigation of multiheme c -type cytochromes in prokaryotes
  22. Protein stability and mutations in the axial methionine loop of a minimal cytochrome c

Search Result: