Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: J Biol Inorg Chem

Search In Journal Title:

Abbravation: JBIC Journal of Biological Inorganic Chemistry

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

ISSN

1432-1327

Search In ISSN:
Search In Title Of Papers:

Ciliate metallothioneins unique microbial eukaryo

Authors: Juan C Gutiérrez F Amaro S Díaz P de Francisco L L Cubas A MartínGonzález
Publish Date: 2011/07/22
Volume: 16, Issue: 7, Pages: 1025-
PDF Link

Abstract

This article represents an updated review of ciliate metallothioneins Tetrahymena species including a comparative analysis with regard to wellknown metallothioneins MTs from other organisms and discussion of their exclusive features It opens with an introduction to ciliates summarizing the main characteristics of these eukaryotic microorganisms and their use as cellular models to study metallothioneins and metal–eukaryotic cell interactions It has been experimentally proved that at least three different metal resistance mechanisms exist in ciliates of which bioaccumulation is the most studied Structural comparative analysis reveals that Tetrahymena MTs have unique characteristics such as longer length a considerably higher cysteine content different metal–MT stoichiometry values the presence of new cysteine clusters and a strictly conserved modular–submodular structure Gene expression analysis reveals a multistress and differential response to diverse metals and other environmental stressors which corroborates the classification of these MTs An in silico analysis of the promoter sequences of some MT genes reveals the presence of conserved motifs that are probably involved in gene expression regulation We also discuss the great advantages of the first ciliate wholecell biosensors based on MT promoters from Tetrahymena thermophila to detect heavy metal ions in environmental samples

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. The Fox1 ferroxidase of Chlamydomonas reinhardtii : a new multicopper oxidase structural paradigm
  2. Impaired hydrolysis of cisplatin derivatives to aquated species prevents energy-dependent uptake in GLC4 cells resistant to cisplatin
  3. Folding of the prion peptide GGGTHSQW around the copper(II) ion: identifying the oxygen donor ligand at neutral pH and probing the proximity of the tryptophan residue to the copper ion
  4. Rates of intercalator-driven platination of DNA determined by a restriction enzyme cleavage inhibition assay
  5. Rates of intercalator-driven platination of DNA determined by a restriction enzyme cleavage inhibition assay
  6. New vanadium-based magnetic resonance imaging probes: clinical potential for early detection of cancer
  7. Effect of complex formation between Zn 2+ ions and the anticancer drug mithramycin upon enzymatic activity of zinc(II)-dependent alcohol dehydrogenase
  8. DNA targeting and cleavage by an engineered metalloprotein dimer
  9. Cobalt hexaamine mediated electrocatalytic voltammetry of dimethyl sulfoxide reductase: driving force effects on catalysis
  10. Structural and thermodynamical properties of Cu II amyloid- β 16/28 complexes associated with Alzheimer’s disease
  11. Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals
  12. The role of axial ligands for the structure and function of chlorophylls
  13. Synthesis and structural characterization of soluble neuromelanin analogs provides important clues to its biosynthesis
  14. Synthesis and crystal structures of novel copper(II) complexes with glycine and substituted phenanthrolines: reactivity towards DNA/BSA and in vitro cytotoxic and antimicrobial evaluation
  15. Enantiopure copper(II) complex of natural product rosin derivative: DNA binding, DNA cleavage and cytotoxicity
  16. Human copper transporter Ctr1 is functional in Drosophila , revealing a high degree of conservation between mammals and insects
  17. A spectroscopic and voltammetric study of the pH-dependent Cu(II) coordination to the peptide GGGTH: relevance to the fifth Cu(II) site in the prion protein
  18. Kinetic and structural studies on roles of the serine ligand and a strictly conserved tyrosine residue in nitrile hydratase
  19. A realistic in silico model for structure/function studies of molybdenum–copper CO dehydrogenase
  20. Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aβ amyloid aggregates
  21. A systematic investigation of multiheme c -type cytochromes in prokaryotes
  22. Protein stability and mutations in the axial methionine loop of a minimal cytochrome c
Search Result: