Authors: Kornelius Zeth Thomas Meins Clemens Vonrhein
Publish Date: 2008/08/09
Volume: 40, Issue: 3, Pages: 127-
Abstract
The voltage dependent anionchannel VDAC is the major constitutive protein of the outer membrane of mitochondria Functionally VDAC is involved in the exchange of small metabolites over the mitochondrial outer membrane and supports enzymes of the cytoplasm with energy precursors ie ATP Moreover the channel alone or in complex with proteins of the inner mitochondrial membrane or the intermembrane space provides a basis for docking of cytosolic proteins which can regulate outer membrane permeability in several ways Structurally this channel has a bacterial origin by evolution and partly resembles bacterial porin functions However the structure seems more complex as a variety of interactions on both channel sides can occur Therefore our work described is aiming to determine the structure of VDAC at atomic resolution and together with functional data to understand better how this channel can carry out such a variety of differing functionsThis article is published under an open access license Please check the Copyright Information section for details of this license and what reuse is permitted If your intended use exceeds what is permitted by the license or if you are unable to locate the licence and reuse information please contact the Rights and Permissions team
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