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Title of Journal: J Bioenerg Biomembr

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Abbravation: Journal of Bioenergetics and Biomembranes

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Springer US

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DOI

10.1007/bf03286866

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1573-6881

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Signaling pathways leading to ischemic mitochondri

Authors: John W Thompson Srinivasan V Narayanan Kevin B Koronowski Kahlilia MorrisBlanco Kunjan R Dave Miguel A PerezPinzon
Publish Date: 2014/09/28
Volume: 47, Issue: 1-2, Pages: 101-110
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Abstract

There is extensive evidence that ischemic/reperfusion mediated mitochondrial dysfunction is a major contributor to ischemic damage However data also indicates that mild ischemic stress induces mitochondrial dependent activation of ischemic preconditioning Ischemic preconditioning is a neuroprotective mechanism which is activated upon a brief subinjurious ischemic exposure and is sufficient to provide protection against a subsequent lethal ischemic insult Current research demonstrates that mitochondria are not only the inducers of but are also an important target of ischemic preconditioning mediated protection Numerous proteins and signaling pathways are activated by ischemic preconditioning which protect the mitochondria against ischemic damage In this review we examine some of the proteins activated by ischemic precondition which counteracts the deleterious effects of ischemia/reperfusion thereby maintaining normal mitochondrial activity and lead to ischemic toleranceThis work was supported by grants from NIH/NINDS NS45676 NS054147 and NS34773 to MAPP and NS073779 to KRD by a NIH F31 Predoctoral award NS08034401 to SVN and by American Heart Association Greater Southeast Affiliate Postdoctoral to JWT and Predoctoral to KBM grants

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