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Title of Journal: J Bioenerg Biomembr

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Abbravation: Journal of Bioenergetics and Biomembranes

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Springer US

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DOI

10.1016/j.aquabot.2009.07.006

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1573-6881

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Electron transport chain dysfunction by HSubscrip

Authors: Christian CortésRojo Mirella EstradaVillagómez Elizabeth CalderónCortés Mónica ClementeGuerrero Ricardo MejíaZepeda Istvan Boldogh Alfredo SaavedraMolina
Publish Date: 2011/02/25
Volume: 43, Issue: 2, Pages: 135-147
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Abstract

The mitochondrial electron transport chain ETC contains thiol groups −SH which are reversibly oxidized to modulate ETC function during H2O2 overproduction Since deleterious effects of H2O2 are not limited to –SH oxidation due to the formation of other H2O2derived species some processes like lipoperoxidation could enhance the effects of H2O2 over ETC enzymes disrupt their modulation by –SH oxidation and increase superoxide production To verify this hypothesis we tested the effects of H2O2 on ETC activities superoxide production and iron mobilization in mitochondria from lipoperoxidationresistant native yeast and lipoperoxidationsensitized yeast Only complex III activity from lipoperoxidationsensitive mitochondria exhibited a higher susceptibility to H2O2 and increased superoxide production The recovery of ETC activity by the thiol reductanct βmercaptoethanol BME was also altered at complex III and a role was attributed to lipoperoxidation the latter being also responsible for iron release A hypothetical model linking lipoperoxidation increased complex III damage superoxide production and iron release is given

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