Molecular Cardiology in Translation Gene Cell an

Authors: Immanuel Turner Fikru BelemaBedada Joshua Martindale DeWayne Townsend Wang Wang Nathan Palpant Sochiro Yasuda Matthew Barnabei Ekaterina Fomicheva Joseph M Metzger

Publish Date: 2008/10/01

Volume: 1, Issue: 4, Pages: 317-327

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Abstract

Acquired and inherited diseases of the heart represent a major health care issue in this country and throughout the World Clinical medicine has made important advancements in the past quarter century to enable several effective treatment regimes for cardiac patients Nevertheless it is apparent that even with the best care current treatment strategies and therapeutics are inadequate for treating heart disease leaving it arguably the most pressing health issue today In this context it is important to seek new approaches to redress the functional deficits in failing myocardium This review focuses on several recent gene cell and chemicalbased experimental therapeutics currently being developed in the laboratory for potential translation to patient care For example new advances in biosensing inducible gene expression systems offer the potential for designer cardioprotective proteins to be expressed only during hypoxia/ischemia in the heart Stem cells continue to offer the promise of cardiac repair and some recent advances are discussed here In addition discovery and applications of synthetic polymers are presented as a chemicalbased strategy for acute and chronic treatment of diseased and failing cardiac tissue Collectively these approaches serve as the front lines in basic biomedical research with an eye toward translation of these findings to clinically meaningful applications in cardiac disease

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