ShortTerm Adjuvant Therapy with Emphasis Type="I

Authors: Divya Kapoor Dimple Trikha Rajesh Vijayvergiya K K Parashar Deepak Kaul Veena Dhawan

Publish Date: 2015/04/01

Volume: 8, Issue: 3, Pages: 173-186

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Abstract

The present study evaluated the cardioprotective effects of Terminalia arjuna on classical and immunoinflammatory markers in coronary artery disease CAD as an adjuvant therapy One hundred sixteen patients with stable CAD were administered placebo/T arjuna 500 mg twice a day along with medications in a randomized doubleblind clinical trial To understand the specificity and efficacy of T arjuna we evaluated its effect through microarray and in silico analysis in few representative samples Data was further validated via realtime PCR n = 50 each at baseline 3 months and 6 months respectively rIL18 cytokine was used to induce inflammation in vitro to compare its effects with atorvastatin T arjuna significantly downregulated TG VLDLC and immunoinflammatory markers in stable CAD versus placebotreated subjects Microarray and pathway analysis of a few samples from T arjuna/placebotreated groups and realtime PCR validation further confirmed our observations Our data demonstrate the antiinflammatory and immunomodulatory effects of T arjuna that may attenuate ongoing inflammation and immune imbalance in medicated CAD subjectsWe are grateful to all the study subjects who participated in the present study and the laboratory staff for their technical support We would also like to acknowledge Biovivid Technology Pvt Ltd Bangalore India for their technical support and suggestions in bioinformatics analysisThe authors wish to thank The Himalaya Drug Company Bangalore for providing the drug as well as financial assistance for microarray analysis Also we wish to thank the Indian Council of Medical Research ICMR New Delhi for awarding Senior Research Fellowship to Ms Divya KapoorAll procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation institutional and national and with the Helsinki Declaration of 1975 as revised in 2000 Informed consent was obtained from all patients for being included in the study

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