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Title of Journal: Curr Atheroscler Rep

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Abbravation: Current Atherosclerosis Reports

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Current Science Inc.

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DOI

10.1007/s00134-004-2418-y

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1534-6242

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Creating a genetic risk score for coronary artery

Authors: Sonny Dandona Robert Roberts
Publish Date: 2009/04/18
Volume: 11, Issue: 3, Pages: 175-
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Abstract

Coronary artery disease CAD and its sequelae represent a significant health burden Over the past two decades numerous studies have attempted to link DNA sequence variation with the risk of CAD and related phenotypes There has been significant evolution in technology from the early linkage studies within kindreds and now we are able to use highdensity genotyping to facilitate largescale genomewide association studies The first novel genetic risk factor for CAD 9p213 has been confirmed and other loci are awaiting replication studies The relative importance of each locus from a global standpoint and the incremental information conferred by testing for genetic variants remain to be determined

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Other Papers In This Journal:
  1. Metabolomics and Atherosclerosis
  2. Alcohol and Cardiovascular Disease: How Much is Too Much?
  3. Soluble Epoxide Hydrolase in Atherosclerosis
  4. The Incremental Value of Lipids and Inflammatory Biomarkers in Determining Residual Cardiovascular Risk
  5. Mediterranean Diet and Cardiovascular Disease: Historical Perspective and Latest Evidence
  6. Oxidized PLs and Vascular Inflammation
  7. Oxidized PLs and Vascular Inflammation
  8. Use of Heparin in Acute Ischemic Stroke: Is There Still a Role?
  9. The omega-3 index: From biomarker to risk marker to risk factor
  10. Postprandial Hypertriglyceridemia and Cardiovascular Disease: Current and Future Therapies
  11. Impact of Gastrointestinal Surgery on Cardiometabolic Risk
  12. Is there a role for the glycemic index in coronary heart disease prevention or treatment?
  13. Is the Future of Statins Aligned with New Novel Lipid Modulation Therapies?
  14. Role of Phospholipid Transfer Protein in High-Density Lipoprotein– Mediated Reverse Cholesterol Transport
  15. The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: Evidence from clinical trials
  16. Increased plasma levels of plant sterols and atherosclerosis: A controversial issue
  17. Treatment of Familial Hypercholesterolemia: Is There a Need Beyond Statin Therapy?
  18. Available Transcatheter Aortic Valve Replacement Technology
  19. The paraoxonase gene family and atherosclerosis
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