Postprandial Hypertriglyceridemia and Cardiovascul

Authors: D C Chan J Pang G Romic G F Watts

Publish Date: 2013/01/24

Volume: 15, Issue: 3, Pages: 309-

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Abstract

Exaggerated postprandial hypertriglyceridemia is a risk factor for cardiovascular disease This metabolic abnormality is principally due to overproduction and/or decreased catabolism of triglyceriderich lipoproteins TRLs and is a consequence of pathogenic genetic variations and other coexistent medical conditions particularly obesity and insulin resistance Accumulation of TRL in the postprandial state promotes the formation of small dense lowdensity lipoproteins as well as oxidative stress inflammation and endothelial dysfunction all of which compound the risk of cardiovascular disease The cardiovascular benefits of lifestyle modification weight loss and exercise and conventional lipidlowering therapies statins fibrates niacin ezetimibe and n3 fatty acid supplementation could involve their favorable effects on TRL metabolism New agents such as dual peroxisomeproliferatoractivated receptor α/δ agonists diacylglycerol inhibitors of diacylglycerol acyltransferase 1 and microsomal triglyceride transfer protein antisense oligonucleotides for apolipoprotein B100 and apolipoprotein CIII and incretinbased therapies may enhance the treatment of postprandial lipemia but their efficacy needs to be tested in clinical end point trials Further work is required to develop a simple clinical protocol for investigating postprandial lipemia as well as internationally agreed management guidelines for this type of dyslipidemia

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