Mediterranean Diet and Cardiovascular Disease His

Authors: Michel de Lorgeril

Publish Date: 2013/10/09

Volume: 15, Issue: 12, Pages: 370-

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Abstract

The concept that the Mediterranean diet was associated with a lower incidence of cardiovascular disease CVD was first proposed in the 1950s Since then there have been randomized controlled trials and large epidemiological studies that reported associations with lower CVD in 1994 and 1999 the reports of the intermediate and final analyses of the trial Lyon Diet Heart Study in 2003 a major epidemiological study in Greece showing a strong inverse association between a Mediterranean score and the risk of cardiovascular complications in 2011–2012 several reports showing that even nonMediterranean populations can gain benefits from longterm adhesion to the Mediterranean diet and in 2013 the PREDIMED trial showing a significant risk reduction in a lowrisk population Contrary to the pharmacological approach of cardiovascular prevention the adoption of the Mediterranean diet has been associated with a significant reduction in new cancers and overall mortality Thus in terms of evidencebased medicine the full adoption of a modern version of the Mediterranean diet pattern can be considered one of the most effective approaches for the prevention of fatal and nonfatal CVD complications

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