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Title of Journal: Curr Atheroscler Rep

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Abbravation: Current Atherosclerosis Reports

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Current Science Inc.

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10.1002/chin.200012117

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1534-6242

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Metabolomics and Atherosclerosis

Authors: Sascha N Goonewardena Lisa E Prevette Ankit A Desai
Publish Date: 2010/05/13
Volume: 12, Issue: 4, Pages: 267-272
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Abstract

Metabolites reflect the dynamic processes underlying cellular homeostasis Recent advances in analytical chemistry and molecular biology have set the stage for metabolite profiling to help us understand complex molecular processes and physiology Metabolomics is the comparative analysis of metabolite flux and how it relates to biological phenotypes As an intermediate phenotype metabolite signatures capture a unique aspect of cellular dynamics that is not typically interrogated providing a distinct perspective on cellular homeostasis To date there have been only a few metabolomics studies investigating cardiovascular diseases In this review we explore the principles of metabolomics and how it can provide further insight into the mechanisms of cardiovascular physiology and ultimately lead to improved diagnostic and therapeutic options for patients with cardiovascular disease


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