Authors: Nam Yeol Yim YunHyeon Kim Song Choi Hyun Ju Seon Yeong Cheol Kim Gwang Woo Jeong Byeong In Min Sang Rok Lee Myeong Ho Jeong Jae Kyu Kim Jin Gyoon Park Heoung Keun Kang
Publish Date: 2009/01/20
Volume: 25, Issue: 1, Pages: 65-74
Abstract
We aimed to develop colorcoded CT perfusion maps CPM of infarcted myocardium and assess the utility of CPM in evaluating ischemic heart disease on a cardiac multidetector CT MDCT in a porcine reperfusedmyocardialinfarction model Myocardial infarctions were induced by 30 min occlusions of the proximal left anterior descending coronary artery LAD in 17 healthy adult female pigs Firstpass and 5 mindelayed cardiac MDCTs were performed after 4 weeks of LAD occlusion Myocardial CPMs were obtained by using the CPM program Triphenyltetrazolium chloride TTCstaining was performed on the cardiac specimens We analyzed the intermodality agreement on the size and location of the myocardial infarctions TTC staining revealed myocardial infarction in 16 of 17 pigs and 15 of these 94 showed matched infarcts on the CPM and firstpass images The areas of perfusion deficit noted in early arterial phase images and CPM coincided exactly with the areas of poor TTC staining in 12 of 15 pigs 80 In the three remaining pigs the areas of poor TTC staining were larger than those of a perfusion deficit demonstrated by either early arterial phase images or CPM The agreement between these tests is calculated to be moderate to good k = 0736 P 005 Ten myocardial segments in 4 of the 15 pigs 27 with hypoattenuated myocardium showed a delayed enhancement on the 5 mindelayed images Contrastenhanced MDCT was useful and accurate in detecting chronic myocardial infarction CPM was helpful in visualizing the infarcted myocardium
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