Authors: Galia Karp Arik Wolak Yael Baumfeld Nina BarAm Victor Novack Talya Wolak Lior Fuchs Aryeh Shalev Ilan Shelef Mahmoud AbuShakra
Publish Date: 2016/02/06
Volume: 32, Issue: 6, Pages: 935-944
Abstract
To evaluate aortic stiffness by MRI in female patients with systemic lupus erythematosus SLE or rheumatoid arthritis RA in comparison to controls We measured aortic strain distensibility and pulse wave velocity PWV by MRI in 30 SLE patients 31 RA patients and 53 matched controls Mean PWV in SLE and RA patients were higher in comparison to controls 92 ± 44 vs 76 ± 30 m/s p = 004 and 62 ± 23 vs 54 ± 17 p = 004 respectively Aortic distensibility among RA patients was significantly lower in comparison to controls 44 ± 46 vs 58 ± 49 kPa−1 × 10−3 p = 004 A significant correlation was found between PWV and age r = 067 p 0001 Framingham risk score r = 061 p 0001 waist to hip ratio r = 045 p 0001 systolic blood pressure r = 037 p = 001 diabetes r = 032 p = 0001 and dyslipidemia r = 032 p = 0001 In multivariate analysis for the prediction of PWV variables which were found significant included RA p = 001 age p 0001 and hypertension p = 001 for patients with RA and SLE p = 002 waist to hip ratio p 0001 and total cholesterol p 0001 for patients with SLE Arterial stiffness characterized by metrics of aortic distensibility and pulse wave velocity derived from MRI is increased in SLE and RA female patients
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