Authors: Hoyoun Won JungSun Kim DongHo Shin ByeongKeuk Kim YoungGuk Ko Donghoon Choi Yangsoo Jang MyeongKi Hong
Publish Date: 2013/11/13
Volume: 30, Issue: 2, Pages: 263-270
Abstract
The use of drugeluting stent DES has been associated with incomplete endothelialization and coronary endothelial dysfunction However the relationship between endothelial vasomotor function and strut coverage evaluated by optical coherence tomography OCT has not been sufficiently assessed Therefore we evaluated the relationship between endothelial vasomotor function and the degree of stent strut coverage after DES implantation Coronary angiography and OCT were performed in 112 patients at the 6month followup after DES implantation The patients were divided into tertiles according to the degree of strut coverage as was assessed by OCT Endothelial vasomotor function was evaluated with intracoronary infusion of incremental doses of acetylcholine Ach 10−8–10−6 mol/L Vascular responses at the proximal and distal segments to the stent margin were evaluated by quantitative coronary angiography analysis before and after Ach infusion The percentage of uncovered struts in tertiles 1–3 was 42 ± 33 173 ± 42 and 445 ± 144 respectively p 0001 The percentage of maximal vasoconstriction in tertiles 1–3 was 83 91 and 81 at proximal segment to the stent margin p = 095 respectively and 139 111 and 142 at distal segment to the stent margin p = 074 respectively The percentage of uncovered struts was not correlated with the degree of vasomotor function r = −001 p = 092 at the proximal segment r = −007 p = 047 at the distal segment The percentage of strut coverage was not associated with the degree of abnormal vasoconstriction in response to intracoronary infusion of Ach 6 months after DES implantationThis study was supported by a grant from the Korea Healthcare Technology RD Project Ministry for Health Welfare Family Affairs Republic of Korea No A085012 and A102064 a grant from the Korea Health 21 RD Project Ministry of Health and Welfare Republic of Korea No A085136 and the Cardiovascular Research Center Seoul Korea
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