EEG and MRI findings and their relation with intel

Authors: Özlem Ünal Özlem Özcan Özgür Öner Melda Akcakin Ayla Aysev Gülhis Deda

Publish Date: 2009/08/20

Volume: 5, Issue: 3, Pages: 196-200

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Abstract

The diagnostic category pervasive developmental disorders PDDs refer to a group of five disorders autism Rett syndrome childhood disintegrative disorder Asperger syndrome and pervasive developmental disorder not otherwise specified PDDNOS EEG abnormalities and seizures are considered much frequent in autistic subjects with comorbid intellectual disability ID In this study we aimed to evaluate the EEG and MRI findings and their relation with ID in pervasive developmental disorderA retrospective crosssectional and nonexperimental study was performed Subjects included 81 patients diagnosed with autism or PDDNOS according to the DSMIV criteria The age range of the patients was 2–15 years mean 66 years SD 30 Among them 21 259 were girls and 60 boys 741Patients with severe ID had a higher rate of EEG abnormalities P=003 than patients without ID as well as patients with mild or moderate ID The association remained significant after the structural MRI abnormalities were controlled P=004 The severity of ID was not associated with abnormal MRI The most frequent EEG and MRI abnormalities were active epileptic anomaly/paroxysmal abnormality and cerebral atrophy/periventricular leukomalacia respectively Almost a third of the EEG abnormalities were associated with temporal cortex and adjacent cortical structuresConsistent with previous studies almost a fourth of the patients in this relatively large sample of patients with pervasive developmental disorders had EEG and/or MRI abnormalities EEG results indicate that temporal cortex may play a significant role in pervasive developmental disorders

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