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Title of Journal: World J Pediatr

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Abbravation: World Journal of Pediatrics

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Childrens Hospital, Zhejiang University School of Medicine

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DOI

10.1007/bf01955685

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1867-0687

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Management of children with disorders of sex devel

Authors: Somchit Jaruratanasirikul Vorapun Engchaun
Publish Date: 2013/06/17
Volume: 10, Issue: 2, Pages: 168-174
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Abstract

Disorders of sex development DSD is a group of sexual differentiation disorders resulting in genital anomalies with defects in gonadal hormone synthesis and/or incomplete genital development These conditions result in problems concerning the sex assignment of the child This study aims to describe the clinical features diagnosis and management of children with DSD in southern ThailandDisorders of sex development were categorized into 3 groups sex chromosome abnormalities 530 46XX DSD 299 and 46XY DSD 171 The two most common etiologies of DSD were Turner syndrome 368 and congenital adrenal hyperplasia 299 Ambiguous genitalia/intersex was the main problem in 46XX DSD 94 and 46XY DSD 100 Sex reassignment was done in 5 children 43 at age of 3–5 years from male to female in 4 children 1 patient with congenital adrenal hyperplasia 1 patient with 45X/46XY DSD and 2 patients with 46XX ovotesticular DSD and from female to male in 1 patient with 46XX ovotesticular DSD Of the total 20 children with 46XY DSD 16 80 were raised as females

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