Hypothalamicpituitaryadrenal axis dysfunction as

Authors: María Dolores Braquehais María Dolores Picouto Miquel Casas Leo Sher

Publish Date: 2012/08/12

Volume: 8, Issue: 3, Pages: 197-206

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Abstract

We conducted a PubMed search of all Englishlanguage articles published between January 1990 and June 2011 using the following search terms “hypothalamicpituitaryadrenal” OR “HPA” AND “adolescence” OR “adolescent” OR “teenager” AND “depression” OR “major depressive disorder” OR “suicidal behavior” OR “suicidal ideation” OR “suicidal thoughts” OR “deliberate selfharm” OR “suicidal attempt” OR “suicide”HPA axis activity can be examined using different methods that do not have the same biological interpretation An abnormal HPA axis functioning together with an anomalous interaction between HPA mechanisms and other systems such as the serotonergic system may be one of the neurobiological correlates of emotion dysregulation ED ED may play an important role in adolescent suicidal behavior Some psychopathological conditions such as depression or childhood psychological trauma that increase suicidal risk in adolescents are also associated with HPA axis dysregulation ED a personality trait can also be viewed as a predisposing factor that augments the vulnerability to suffer from psychiatric conditions

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