Journal Title
Title of Journal: World J Pediatr
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Abbravation: World Journal of Pediatrics
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Publisher
Childrens Hospital, Zhejiang University School of Medicine
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Authors: ZhangBin Yu ShuPing Han Chao Chen
Publish Date: 2014/08/15
Volume: 10, Issue: 3, Pages: 211-218
Abstract
Hyperbilirubinemia occurs in most healthy term and latepreterm infants and must be monitored to identify those who might develop severe hyperbilirubinemia Total serum bilirubin TSB or transcutaneous bilirubin TcB nomograms have been developed and validated to identify neonatal hyperbilirubinemia This study aimed to review previously published studies and compare the TcB nomograms with the TSB nomogram and to determine if the former has the same predictive value for significant hyperbilirubinemia as TSB nomogram doesA predefined search strategy and inclusion criteria were set up We selected studies assessing the predictive ability of TSB/TcB nomograms to identify significant hyperbilirubinemia in healthy term and latepreterm infants Two independent reviewers assessed the quality and extracted the data from the included studies MetaDisc 14 analysis software was used to calculate the pooled sensitivity specificity and positive likelihood ratio of TcB/TSB nomograms A pooled summary of the receiver operating characteristic of the TcB/TSB nomograms was createdAfter screening 187 publications from electronic database searches and reference lists of eligible articles we included 14 studies in the systematic review and metaanalysis Eleven studies were of medium methodological quality The remaining three studies were of low methodological quality Seven studies evaluated the TcB nomograms and seven studies assessed TSB nomograms There were no differences between the predictive abilities of the TSB and TcB nomograms the pooled area under curve was 0819 vs 0817This study showed that TcB nomograms had the same predictive value as TSB nomograms both of which could be used to identify subsequent significant hyperbilirubinemia But this result should be interpreted cautiously because some methodological limitations of these included studies were identified in this review
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