Journal Title
Title of Journal: J Neuroimmune Pharmacol
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Abbravation: Journal of Neuroimmune Pharmacology
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Authors: Rajeshwara N Achur Willard M Freeman Kent E Vrana
Publish Date: 2009/12/18
Volume: 5, Issue: 1, Pages: 83-91
Abstract
There are currently no consistent objective biochemical markers of alcohol abuse and alcoholism Development of reliable diagnostic biomarkers that permit accurate assessment of alcohol intake and patterns of drinking is of prime importance to treatment and research fields Diagnostic biomarker development in other diseases has demonstrated the utility of both open systems biology screening for biomarkers and more rational focused efforts on specific biomolecules or families of biomolecules Longterm alcohol consumption leads to altered inflammatory cell and adaptive immune responses with associated pathologies and increased incidence of infections This has led researchers to focus attention on identifying cytokine biomarkers in models of alcohol abuse Alcohol is known to alter cytokine levels in plasma and a variety of tissues including lung liver and very importantly brain A number of cytokine biomarker candidates have been identified including tumor necrosis factoralpha interleukin IL1alpha IL1beta IL6 IL8 IL12 and monocyte chemoattractant protein1 This is an emerging and potentially exciting avenue of research in that circulating cytokines may contribute to diagnostic biomarker panels and a combination of multiple biomarkers may significantly increase the sensitivity and specificity of the biochemical tests aiding reliable and accurate detection of excessive alcohol intake
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