On the Connection Between Autoimmunity tic Disord

Authors: Marco Pozzi Paolo Pellegrino Carla Carnovale Valentina Perrone Stefania Antoniazzi Cristiana Perrotta Sonia Radice Emilio Clementi

Publish Date: 2014/08/05

Volume: 9, Issue: 5, Pages: 606-614

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Abstract

Antistreptolysin O ASO titration is useful in the context of autoimmune pathologies including specific cases of tic and obsessivecompulsive disorders occurring after streptococcal infections There is currently a lack of consensus on the use of ASO titres therefore we performed a metaanalysis to systematise available data and clarify the role of ASO titres in the context of neuropsychiatric disorders A metaanalysis was performed on ASO titration in neuropsychiatric patients including tic disorders and obsessivecompulsive disorders Included studies reported numbers of positive subjects depending on a chosen threshold or detailed ASO titrations Three hundred and twenty nine studies were identified of which 13 were eligible for metaanalysis Due to limited available data only tic disorders were evaluated The odds ratio of finding an abnormal ASO titre in patients was 322 95  CI 151–688 as compared to healthy controls and 1614 95  CI 811–3211 as compared to nonpsychiatric patients Studies using different thresholds were generally concordant ASO titres were also compared quantitatively finding an overall difference of the means of 7050 U/ml 95  CI 2521–11580 in favour of patients with tic disorders Based on current evidence tic disorders are associated with a significant increase in ASO titres evident both in a thresholdlevel perspective and on a quantitative level These results encourage the systematisation of ASO titration in the context of tic disordersThe financial support by Agenzia Italiana del Farmaco AIFA and by the Italian Ministry of Health Ricerca Corrente 2014 to EC is gratefully acknowledged The authors report no conflict of interests The funding public institutions had no role in any part of the work

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