Mechanisms of Dendritic Cell Trafficking Across th

Authors: Divya Sagar Catherine Foss Rasha El Baz Martin G Pomper Zafar K Khan Pooja Jain

Publish Date: 2011/08/06

Volume: 7, Issue: 1, Pages: 74-94

PDF Link

Abstract

Although the central nervous system CNS is considered to be an immunoprivileged site it is susceptible to a host of autoimmune as well as neuroinflammatory disorders owing to recruitment of immune cells across the blood–brain barrier into perivascular and parenchymal spaces Dendritic cells DCs which are involved in both primary and secondary immune responses are the most potent immune cells in terms of antigen uptake and processing as well as presentation to T cells In light of the emerging importance of DC traficking into the CNS these cells represent good candidates for targeted immunotherapy against various neuroinflammatory diseases This review focuses on potential physiological events and receptor interactions between DCs and the microvascular endothelial cells of the brain as they transmigrate into the CNS during degeneration and injury A clear understanding of the underlying mechanisms involved in DC migration may advance the development of new therapies that manipulate these mechanistic properties via pharmacologic intervention Furthermore therapeutic validation should be in concurrence with the molecular imaging techniques that can detect migration of these cells in vivo Since the use of noninvasive methods to image migration of DCs into CNS has barely been explored we highlighted potential molecular imaging techniques to achieve this goal Overall information provided will bring this important leukocyte population to the forefront as key players in the immune cascade in the light of the emerging contribution of DCs to CNS health and disease

Keywords: