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Title of Journal: Med Biol Eng Comput

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Abbravation: Medical & Biological Engineering & Computing

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Springer-Verlag

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10.1002/chin.199518163

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1741-0444

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Mathematical modeling of electrical activity of ut

Authors: Sandy Rihana Jeremy Terrien Guy Germain Catherine Marque
Publish Date: 2009/03/20
Volume: 47, Issue: 6, Pages: 665-675
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Abstract

The uterine electrical activity is an efficient parameter to study the uterine contractility In order to understand the ionic mechanisms responsible for its generation we aimed at building a mathematical model of the uterine cell electrical activity based upon the physiological mechanisms First based on the voltage clamp experiments found in the literature we focus on the principal ionic channels and their cognate currents involved in the generation of this electrical activity Second we provide the methodology of formulations of uterine ionic currents derived from a wide range of electrophysiological data The model is validated step by step by comparing simulated voltageclamp results with the experimental ones The model reproduces successfully the generation of single spikes or trains of action potentials that fit with the experimental data It allows analyzing ionic channels implications Likewise the calciumdependent conductance influences significantly the cellular oscillatory behaviorThis work was supported by a grant “Pôle GBM PérinatalitéEnfance” of the Picardy Region France It has been communicated and poster presented in proceedings of the third European Medical and Biological Engineering Conference EMBC held in Prague in November 2005

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