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Title of Journal: Med Biol Eng Comput

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Abbravation: Medical & Biological Engineering & Computing

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Springer-Verlag

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10.1016/0002-9378(57)90543-4

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1741-0444

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Theoretical development and critical analysis of b

Authors: Tzer Hwai Gilbert Thio Salar Soroori Fatimah Ibrahim Wisam AlFaqheri Norhayati Soin Lawrence Kulinsky Marc Madou
Publish Date: 2013/01/06
Volume: 51, Issue: 5, Pages: 525-535
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Abstract

This paper presents a theoretical development and critical analysis of the burst frequency equations for capillary valves on a microfluidic compact disc CD platform This analysis includes background on passive capillary valves and the governing models/equations that have been developed to date The implicit assumptions and limitations of these models are discussed The fluid meniscus dynamics before bursting is broken up into a multistage model and a more accurate version of the burst frequency equation for the capillary valves is proposed The modified equations are used to evaluate the effects of various CD design parameters such as the hydraulic diameter the height to width aspect ratio and the opening wedge angle of the channel on the burst pressureMM SS and LK would like to acknowledge support of the National Institute of Health grant 1 R01 AI08954101 MM also acknowledges support of WCU World Class University program R322008000200540 through the National Research Foundation of Korea funded by the Ministry of Education Science and Technology

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