Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Med Biol Eng Comput

Search In Journal Title:

Abbravation: Medical & Biological Engineering & Computing

Search In Journal Abbravation:

Publisher

Springer Berlin Heidelberg

Search In Publisher:

DOI

10.1002/cite.200700087

Search In DOI:

ISSN

1741-0444

Search In ISSN:
Search In Title Of Papers:

A spectral element method with adaptive segmentati

Authors: Calvin D Eiber Socrates Dokos Nigel H Lovell Gregg J Suaning
Publish Date: 2016/08/19
Volume: 55, Issue: 5, Pages: 823-831
PDF Link

Abstract

The capacity to quickly and accurately simulate extracellular stimulation of neurons is essential to the design of nextgeneration neural prostheses Existing platforms for simulating neurons are largely based on finitedifference techniques due to the complex geometries involved the more powerful spectral or differential quadrature techniques cannot be applied directly This paper presents a mathematical basis for the application of a spectral element method to the problem of simulating the extracellular stimulation of retinal neurons which is readily extensible to neural fibers of any kind The activating function formalism is extended to arbitrary neuron geometries and a segmentation method to guarantee an appropriate choice of collocation points is presented Differential quadrature may then be applied to efficiently solve the resulting cable equations The capacity for this model to simulate action potentials propagating through branching structures and to predict minimum extracellular stimulation thresholds for individual neurons is demonstrated The presented model is validated against published values for extracellular stimulation threshold and conduction velocity for realistic physiological parameter values This model suggests that convoluted axon geometries are more readily activated by extracellular stimulation than linear axon geometries which may have ramifications for the design of neural prosthesesThe authors would like to thank Dr Tianruo Gou for his generous assistance in providing the parameters of the ion channel model and the expertise to translate its implementation We would also like to thank Chih John Yang and Dr Andrew Wooley for providing the detailed anatomical images of RGCs used in this workThis research was supported by the National Health and Medical Research Council APP1087224 Australia and the Australian Research Council through its Special Research Initiative in Bionic Vision Science and Technology granted to Bionic Vision AustraliaAll applicable international national and institutional guidelines for the care and use of animals were followed All procedures performed involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted Surgical and experimental procedures were reviewed and conducted with approval from the UNSW Animal Care and Ethics Committee

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Lagged segmented Poincaré plot analysis for risk stratification in patients with dilated cardiomyopathy
  2. Chest wall motion analysis in healthy volunteers and adults with cystic fibrosis using a novel Kinect-based motion tracking system
  3. Real-time visual feedback for gait retraining: toward application in knee osteoarthritis
  4. A fast time-difference inverse solver for 3D EIT with application to lung imaging
  5. Computational fluid dynamics-based study of possibility of generating pulsatile blood flow via a continuous-flow VAD
  6. A hybrid algorithm for solving the EEG inverse problem from spatio-temporal EEG data
  7. Acceleration of cardiac tissue simulation with graphic processing units
  8. Effectiveness of medical equipment donations to improve health systems: how much medical equipment is broken in the developing world?
  9. Synthetic dataset generation for the analysis and the evaluation of image-based hemodynamics of the human aorta
  10. Adapted filter banks for feature extraction in transcranial magnetic stimulation evoked responses
  11. Theoretical development and critical analysis of burst frequency equations for passive valves on centrifugal microfluidic platforms
  12. An automatic method for arterial pulse waveform recognition using KNN and SVM classifiers
  13. A simplification of Cobelli’s glucose–insulin model for type 1 diabetes mellitus and its FPGA implementation
  14. Accuracy and efficacy of thoracic pedicle screws in scoliosis with patient-specific drill template
  15. Effects of CT resolution and radiodensity threshold on the CFD evaluation of nasal airflow
  16. An informative probability model enhancing real time echobiometry to improve fetal weight estimation accuracy
  17. Mathematical modeling of electrical activity of uterine muscle cells
  18. Mathematical models of passive motion at the human ankle joint by equivalent spatial parallel mechanisms
  19. Three-dimensional segmentation of retroperitoneal masses using continuous convex relaxation and accumulated gradient distance for radiotherapy planning
  20. Empirical mode decomposition: a method to reduce low frequency interferences from surface electroenterogram
  21. CT image-based computer-aided system for orbital prosthesis rehabilitation
  22. Video analysis of Hammersmith lateral tilting examination using Kalman filter guided multi-path tracking
  23. Novel registration-based framework for CT angiography in lower legs
  24. Dielectric relaxation of a protein–water system in atherosclerotic artery wall
  25. Cell segmentation in histopathological images with deep learning algorithms by utilizing spatial relationships
  26. A method to qualitatively assess arm use in stroke survivors in the home environment
  27. A method to qualitatively assess arm use in stroke survivors in the home environment
  28. Patient-specific surgical planning and hemodynamic computational fluid dynamics optimization through free-form haptic anatomy editing tool (SURGEM)
  29. Heart rate analysis by sparse representation for acute pain detection
  30. Usefulness of biological fingerprint in magnetic resonance imaging for patient verification
  31. Relation of fetal heart rate signals with unassignable baseline to poor neonatal state at birth
  32. Detection of cardiovascular risk from a photoplethysmographic signal using a matching pursuit algorithm
  33. Time-varying signal analysis to detect high-altitude periodic breathing in climbers ascending to extreme altitude
  34. Effective identification and localization of immature precursors in bone marrow biopsy
  35. A new layered sensor for simultaneous measurement of EMG, MMG and oxygen consumption at the same position
  36. Hemodynamic impact of abdominal aortic aneurysm stent-graft implantation-induced stenosis
  37. Sensitivity studies of pediatric material properties on juvenile lumbar spine responses using finite element analysis
  38. Automatic messaging for improving patients engagement in diabetes management: an exploratory study
  39. Effects of head size and morphology on dynamic responses to impact loading
Search Result: