Journal Title
Title of Journal: Arch Environ Contam Toxicol
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Abbravation: Archives of Environmental Contamination and Toxicology
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Publisher
Springer-Verlag
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Authors: Giuliana G K Botelho Munisa Golin Aedra C Bufalo Rosana N Morais Paulo R Dalsenter Anderson J MartinoAndrade
Publish Date: 2009/03/28
Volume: 57, Issue: 4, Pages: 777-784
Abstract
Phthalates are chemicals employed in several industrial products and there is a growing body of evidence demonstrating that they induce numerous adverse effects on the reproductive system This study was carried out to assess possible alterations induced by the plasticizer di2ethylhexyl phthalate DEHP on cholesterol testosterone and thyroxine total T4 levels as well as to discuss the significance of these data in global changes observed in the reproductive tract of pubertal animals Wistar rats aged 21 days received DEHP orally at 0 250 500 and 750 mg/kg/day for 30 days and were examined for different reproductive endpoints At the end of the treatment significant decreases in relative weight of testosteronedependent organs delayed preputial separation and low serum testosterone were observed at the highest DEHP dose The plot of the relationship between DEHP dose and serum cholesterol revealed a biphasic effect The concentration of cholesterol in serum was significantly reduced at 250 mg/kg/day DEHP but returned to control values at 750 mg/kg/day Cholesterol levels measured in testicular tissue increased with DEHP treatment Serum T4 levels were not affected by DEHP at any dose indicating the absence of a link between total thyroxin concentration and phthalate effects on cholesterol levels Taken together these results indicate that effects observed in serum and testicular cholesterol levels may reflect distinct effects of DEHP on cholesterol synthesis and usage These results confirm and extend previously reported findings showing that alterations in cholesterol balance may play a role in the suppression of steroidogenesis induced by DEHP in rats
Keywords:
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