δAminolevulinic Acid Dehydratase Single Nucleotid

Authors: Christina Sobin Natali Parisi Tanner Schaub Marisela Gutierrez Alma X Ortega

Publish Date: 2011/02/16

Volume: 61, Issue: 3, Pages: 521-529

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Abstract

Child lowlevel lead Pb exposure is an unresolved public health problem and an unaddressed child health disparity Particularly in cases of lowlevel exposure source removal can be impossible to accomplish and the only practical strategy for reducing risk may be primary prevention Genetic biomarkers of increased neurotoxic risk could help to identify small subgroups of children for early intervention Previous studies have suggested that by way of a distinct mechanism δaminolevulinic acid dehydratase single nucleotide polymorphism 2 ALAD2 and/or peptide transporter 22 haplotype hPEPT22 increase Pb blood burden in children Studies have not yet examined whether sex mediates the effects of genotype on blood Pb burden Also previous studies have not included blood iron Fe level in their analyses Blood and cheek cell samples were obtained from 306 minority children ages 51 to 129 years 208Pb and 56Fe levels were determined with inductively coupled plasma–mass spectrometry General linear model analyses were used to examine differences in Pb blood burden by genotype and sex while controlling for blood Fe level The sample geometric mean Pb level was 275 μg/dl Pb blood burden was differentially higher in ALAD2 heterozygous boys and hPEPT22 homozygous boys These results suggest that the effect of ALAD2 and hPEPT22 on Pb blood burden may be sexually dimorphic ALAD2 and hPEPT22 may be novel biomarkers of health and mental health risks in male children exposed to low levels of PbThis research was made possible by grants from the National Institute of Child Health and Human Development National Institutes of Health Grant No R21HD060120 the National Center for Research Resources a component of the National Institutes of Health Grant No 5G12RR008124 the Center for Clinical and Translational Science The Rockefeller University New York NY the Paso del Norte Health Foundation and the University Research Institute University of Texas El Paso TX The funding agencies had no role in the design implementation data analysis or manuscript preparation for this study

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