Authors: Kimihide Kusafuka Hideaki Itoh Chiho Sugiyama Takashi Nakajima
Publish Date: 2010/09/21
Volume: 43, Issue: 3, Pages: 178-184
Abstract
Salivary duct carcinoma SDC is a highly aggressive malignancy of the salivary glands However one type of SDC which shows minimal invasion and better prognosis is known as lowgrade SDC LGSDC This report presents an additional case of LGSDC of the parotid gland The patient was a 38yearold Japanese woman who noticed painless swelling of the left parotid region Grossly the cut surface of the tumor was cystic Microscopically the tumor showed a multicystic pattern which was lined by eosinophilic to clear atypical cells with cribriform or Roman bridge patterns An immunohistochemical examination revealed the tumor was positive for cytokeratin CK 7 and epithelial membrane antigen partially positive for androgen receptor and gross cystic disease fluid protein15 and diffusely positive for Her2/Neu progesterone and estrogen receptors The cancer cells showed focal immunopositivity for S100 protein Immunostaining for p63 CK14 and calponin showed an in situ pattern in most areas of this tumor whereas the tumor showed minimal invasion The cancer cells were diffusely positive for MUC1 and MUC6 and focally positive for MUC2 and MUC4 Finally the tumor was diagnosed to be LGSDC The differential diagnosis and the mucin pattern were evaluated
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