ATF2 immunoreactivity in postmitotic and termina

Authors: Nurullah Keklikoglu Sevtap Akinci

Publish Date: 2014/11/23

Volume: 48, Issue: 3, Pages: 164-168

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Abstract

Activating transcription factor 2 ATF2/CREBP1 cAMPresponsive element binding protein 1 is a member of nuclear transcription factor activator protein1 AP1 family AP1 regulates cellular processes including growth proliferation differentiation and apoptosis However biological relationship of cellular process to each member of the AP1 family is not clear yet The objective of the present study was to compare the ATF2 immunoreactivity in the postmitotic and terminally differentiated odontoblasts and in the pulpal fibroblasts which can be divided by mitosis when required Fibroblasts at various stages of differentiation coexist in the human dental pulp ATF2 was investigated immunohistochemically in 20 permanent human teeth According to the findings obtained the mean percentage of ATF2 positive cells was 685 ± 192  in the odontoblasts and 228 ± 137  in the pulpal fibroblasts The comparison of ATF2 positivity revealed a statistically significant difference between odontoblasts and pulpal fibroblasts These findings have suggested that ATF2 is more associated with cell survival rather than cell proliferation and revealed much of effectiveness in maintaining terminal differentiation than the various differentiation stages of the cellsThe authors wish to thank Dr Humeyra Kocaelli Istanbul University Faculty of Dentistry Department of Oral Surgery and Medicine Istanbul Turkey for her valuable contribution in providing the necessary materials for this research and Biologist Ilker Bolat Istanbul University Faculty of Dentistry Department of Histology and Embryology Istanbul Turkey for his assistance during the experimental work

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