Immunohistochemical study of metaplastic carcinoma

Authors: Rin Yamaguchi Maki Tanaka Keiko Kondo Toshiro Yokoyama Ichiro Maeda Shinichi Tsuchiya Miki Yamaguchi Ryuji Takahashi Yutaka Ogata Hideyuki Abe Jun Akiba Osamu Nakashima Masayoshi Kage Hirohisa Yano

Publish Date: 2012/03/20

Volume: 45, Issue: 1, Pages: 14-21

PDF Link

Abstract

Metaplastic breast cancers MBCs spindle cell carcinoma SpCC squamous cell carcinoma SCC and matrixproducing carcinoma MPC and invasive carcinomas with central acellular zones CACs were analyzed with respect to biological potential by immunohistochemical analyses Specimens from 40 patients 20 with MBCs 7 with SCC 6 with SpCC 5 with MPC and 2 with mixed type and 20 with CACs were analyzed using antibodies to cytokeratin CK 8 5/6 14 AE1/AE3 34αE12 involucrin ckit vimentin VIM alphasmooth muscle actin p63 epidermal growth factor receptor epithelial cell adhesion molecule and estrogen receptor ER/progesterone receptor PR/HER2 Expression of CK5/6 34βE12 VIM nuclear p63 and cytoplasmic p63 was significantly higher with MBCs than CACs 38/13 70/43 85/33 68/40 and 48/18 respectively Other markers were expressed at various levels in these tumors but the difference between them was not significant Eighteen MBC and 8 CAC cases were triple ER/PR/HER2 negative 17 MBCs and 7 CACs were basallike tumors Several differences were seen in MBCs and CACs but they were heterogeneous differentiating multipotentially into mesenchymal myoepithelial basallike phenotypes with “stem celllike” features Thus CACs are related to MBCs by immunohistochemical analyses as well as according to morphological findings

Keywords: