Authors: K E Mulier A H Nguyen J P Delaney S Marquez
Publish Date: 2011/01/15
Volume: 15, Issue: 3, Pages: 315-319
Abstract
Incisional hernias repaired with mesh can be expected have a lower recurrence rate than with primary repair Biologic implants have replaced synthetic meshes in certain complex settings We compared two porcinedermis derived implants—crosslinked Permacol™ biologic implant and noncross linked Stratticefirm™ tissue matrix—in a ventral hernia animal model Our hypothesis is that crosslinked biologic implants are remodeled differently and thus behave differently than noncrosslinked biologic implantsEightynine female SpragueDawley rats had a 3 × 3 cm fullthickness segment of the abdominal wall excised A 3 × 3 cm biologic mesh either Permacol™ or Strattice™ was secured and the skin was closed At 1 3 6 and 12month time intervals rats in each group were sacrificed and the mesh was excised The number of adhesions surface area mesh thickness and tensile strength were determined and immunohistochemical analysis performedPermacol™ biologic implant maintained thickness while Strattice™ thickness decreased significantly starting at 3 months Adhesion area and tenacity were not significantly different between Permacol™ and Strattice™ at all time points The tensile strength of the Permacol™ biologic implant was greater than that of Strattice™ at 3 6 and 12 months Migration of host cells and neovascularization was observed in both implant groups
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