Journal Title
Title of Journal: JICS
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Abbravation: Journal of the Iranian Chemical Society
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Publisher
Springer-Verlag
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Authors: L R Singh N K Poddar T A Dar S Rahman R Kumar F Ahmad
Publish Date: 2012/08/04
Volume: 8, Issue: 1, Pages: 1-23
Abstract
Most organisms that have adapted to environmental stresses have done so by production and accumulation of certain small organic molecules known as osmolytes that arose by natural selection and have the ability to stabilize intracellular proteins against the environmental stress It is well known that osmolytes stabilize proteins and induce folding of aberrant proteins and therefore it is of therapeutic use for a large number of protein misfolding diseases Thus it is very important that the present knowledge of the ability and mechanism of osmolyteinduced protein folding and structural stabilization should reach to researchers working in different avenues In around 40 years of research we have gained great advances in various aspects of protein folding and structural stabilization induced by osmolytes To summarize and discuss the original findings many short review articles and few long reviews have also been available but almost all have focuses on specific aspects To get a clear picture of the effect of osmolytes on protein folding and structural stabilization it is necessary for the benefits of the general readers to combine and discuss all findings made during its 40 years of life This review article is therefore designed to give a collective knowledge on almost all facets of the progresses made on osmolyteprotein interaction todate
Keywords:
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- Dissolved carbon dioxide flotation-assisted in-syringe dispersive liquid–liquid microextraction coupled with microsampling flame atomic absorption spectrometry for selective determination of palladium in water samples
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