Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: J IRAN CHEM SOC

Search In Journal Title:

Abbravation: Journal of the Iranian Chemical Society

Search In Journal Abbravation:

Publisher

Springer Berlin Heidelberg

Search In Publisher:

DOI

10.1007/s40309-015-0078-5

Search In DOI:

ISSN

1735-2428

Search In ISSN:
Search In Title Of Papers:

Synthesis characterization lipoxygenase inhibito

Authors: Sadaf Mutahir Muhammad Yar Muhammad Asim Khan Nisar Ullah Sohail Anjum Shahzad Islam Ullah Khan Rana Atif Mehmood Muhammad Ashraf Rumana Nasar Eleni Pontiki
Publish Date: 2014/12/14
Volume: 12, Issue: 6, Pages: 1123-1130
PDF Link

Abstract

In this paper we have screened a library of two different series of compounds to identify potent lipoxygenase LOX inhibitors A number of new biphenyl bisbenzenesulfonamides 2–3 indol3ylbenzenesulfonyl and acetohydrazides 4–5 and indol3ylhydrazinecarboxylate 6 were synthesized and evaluated in vitro for LOX inhibitory activity Compounds biphenyl bisbenzenesulfonamide 2a and indol3ylbenzenesulfonylhydrazide 4e presented the best antiLOX activity within these series with IC50 values 9631 ± 018 and 8121 ± 214 μM respectively The results were confirmed with docking studies

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Facile and efficient preparation of nitriles through FeCl 4 –IL–SiO 2 -catalyzed direct oxidation of alcohols with hydrogen peroxide
  2. Adsorption behavior of cadmium ion onto synthetic ferrihydrite: effects of pH and natural seawater ligands
  3. Fluoroferrate templated with HAmTAZ: X-ray single crystal, thermal behaviour, vibrational study and magnetic characterization
  4. Carbon dots: synthetic methods and applications as fluorescent probes for the detection of metal ions, inorganic anions and organic molecules
  5. Synthesis and characterization of chitosan coating of NiFe 2 O 4 nanoparticles for biomedical applications
  6. DFT study of CH 4 adsorption on the (5,0), (4,4), (5,5) and (6,6) single-walled carbon nanotubes. Calculated binding energies, NMR and NQR parameters
  7. Ionic liquid functionalized cellulose as an efficient heterogeneous catalyst for the facile and green synthesis of benzoxazine, pyrazine and quinoxaline derivatives in aqueous media
  8. A proton transfer and a nickel(II) compound including pyridine-2,6-dicarboxylate and Phenylhydrazinium ions: Synthesis, characterization, crystal structure and solution study
  9. Pharmacophore interactions analysis and prediction of inhibitory activity of 1,7-diazacarbazoles as checkpoint kinase 1 inhibitors: application of molecular docking, 3D-QSAR and RBF neural network
  10. Using thiourea ligand of gold-thiourea complex to facile direct synthesis of silica@gold core–shell nanostructures
  11. Synthesis and characterization of RuO 2 @ZrO 2 core–shell nano particles as heterogeneous catalyst for oxidation of benzylic alcohols in different conditions
  12. Adsorption of Pb(II) on a composite material prepared from polystyrene-alumina and activated carbon: Kinetic and thermodynamic studies
  13. Nuclear magnetic resonance study of the stoichiometry and stability of several HgX 2 –acetylemethylentriparatolylphosphorane complexes in various acetone–dimethylformamide mixtures
  14. A mild and clean Baeyer–Villiger oxidation of ketones using sodium peroxydisulfate as oxidant catalyzed by silica-supported aluminum chloride
  15. Dissolved carbon dioxide flotation-assisted in-syringe dispersive liquid–liquid microextraction coupled with microsampling flame atomic absorption spectrometry for selective determination of palladium in water samples
  16. Facile and efficient synthesis of pyrimido[1,2- a ]benzimidazole and tetrahydrobenzimidazo[2,1- b ]quinazolin-1(2 H )-one derivatives using Brönsted acidic ionic liquid supported on rice husk ash (RHA-[pmim]HSO 4 )
  17. Photodegradation of 2-nitrophenol catalyzed by CoO, CoS and CoO/CoS nanoparticles
  18. Forty years of research on osmolyte-induced protein folding and stability
  19. Characterization of galena surfaces and potassium isoamyl xanthate (KIAX) synthesized adsorption
  20. Doping of copper (I) oxide onto a solid support as a recyclable catalyst for acetylation of amines/alcohols/phenols and synthesis of trisubstituted imidazole
  21. A brief review of structural concepts of novel supramolecular proton transfer compounds and their metal complexes (part II)
  22. Facile and simple synthesis of pyrimido[4,5- d ]pyrimidinones and pyrano[2,3- d ]pyrimidinones catalyzed by nano-sized NS-C 4 (DABCO-SO 3 H) 2 ·4Cl
  23. The first report on the synthesis of new hantzsch N -Ethyldimetyl Acetal-1,4-dihydropyridines with aldehyde synthon under microwave irradiation
  24. An in silico approach to design peptide mimetics based on docking and molecular dynamics simulation of EGFR–matuzumab complex
  25. Aqua-mediated one-pot synthesis of Biginelli dihydropyrimidinone/thiones (DHPMs), Hantzsch dihydropyridines (DHPs), and polysubstituted pyridines sonocatalyzed by metal-supported nanocatalysts
  26. Application of SBA-Pr-NH 2 in one-pot three-component reaction of methylene-carbonyl compounds, acenaphthenequinone, malononitriles and exploration of its antimicrobial activity
  27. Photo-degradation study of dacarbazine by spectrophotometric–chemometrics and HPLC methods
  28. Hollow fiber solid phase microextraction coupled to square wave anodic stripping voltammetry for selective preconcentration and determination of trace levels of mercury in liquid fuel samples
Search Result: