Onychomycosis Due to Emphasis Type="Italic"Neosc

Authors: Ígor B Cursi Roberta Teixeira Silva Isabella Brasil Succi Andréa R BernardesEngemann Rosane OrofinoCosta

Publish Date: 2012/09/14

Volume: 175, Issue: 1-2, Pages: 75-82

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Abstract

Onychomycosis by Neoscytalidium constitutes chronic infection of the nails and its frequency has increased in recent decades Currently no effective standard treatment exists and literature data remain scarce This work aimed to conduct a pilot project of combined treatment for this infectionThirty patients were divided into three treatment groups oral terbinafine plus ciclopirox nail lacquer twice a week ciclopirox nail lacquer twice a week and ciclopirox nail lacquer 5 days a week all associated with nail abrasion when required for 12 months with 6 months posttreatment followup Clinical and mycological criteria were used for evaluationTwentyfive patients completed the study Significant clinical lesion reduction in disease occurred in all three treatment groups 21 patients 84  entered the study with more than 50  of diseased nail plate at the end of treatment and at 6month followup 84 and 96  respectively presented less than 25  nail lesion Negative microscopy was observed in 36  of the patients at the end of treatment and in 24  of the patients at 6month followup At treatment completion 12 months culture was negative in 21 patients 84  and in 18 72  at followup It was not possible to establish any clinical or mycological statistical differences between groups p  005 Global medical evaluation upon treatment completion revealed that one patient 4  presented complete cure 8 32  presented partial cure 16 64  presented therapeutic failure At the end of followup period 6 patients 24  were considered to have recurrence/reinfectionThe results obtained at the 6month period of followup showed marked improvement 96  of clinical improvement and 72  of negative culture of the patients treated for onychomycosis caused by Neoscytalidium in the three tested groups with no statistical differences between them Multicentric studies with greater number of patients enrolled are necessary to confirm these results

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