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Title of Journal: Arch Microbiol

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Abbravation: Archives of Microbiology

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Springer-Verlag

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DOI

10.1016/0024-3205(83)90828-7

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1432-072X

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Identification of fitness determinants in Emphasi

Authors: Angela G Lindenstrauß Jürgen Behr Matthias A Ehrmann Dirk Haller Rudi F Vogel
Publish Date: 2012/12/13
Volume: 195, Issue: 2, Pages: 121-130
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Abstract

Enterococcus E faecalis is found as commensal in healthy humans in a variety of fermented foods It can serve as probiotic but also as pathogen causing endocarditis bacteremia and urinary tract infections We have employed a proteomic study with E faecalis strain OG1RF under different growth conditions and in contact to mouse intestinal cells to identify novel latent and adaptive fitness determinants These relate to changes in catabolic pathways BudA protein biosynthesis AsnS cellular surface biosynthesis RmlA and regulatory mechanisms OmpR This knowledge can be used to derive novel evidencebased targets which can be used to further elucidate gene expression changes enhancing pathogenicity or fitness in a commensal strain and possibly delineate this species into groups of higher and lower risk for applications in a food or a medical context versus improved treatment strategies of the so far hard to cure diseases

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  2. Tellurite-induced carbonylation of the Escherichia coli pyruvate dehydrogenase multienzyme complex
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