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Title of Journal: Front Med

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Abbravation: Frontiers of Medicine

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Higher Education Press

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DOI

10.1007/bf00606833

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2095-0225

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Pathogenesis sequences in Gejiu miners with lung c

Authors: Bian Li Yonghua Ruan Liju Ma Hairong Hua Zhou Li Xiaoyu Tuo Zheyan Zhou Ting Li Shiyue Liu Kewei Jin
Publish Date: 2015/07/10
Volume: 9, Issue: 3, Pages: 344-349
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Abstract

Tin miners in Gejiu Yunnan Province China are at high risk of developing lung cancer with significant occupational characteristics Tissue samples from these miners presented pathological characteristics such as fibroplasia in carcinomas pericancerous tissue in lung cancers and hyperplasia and dysplasia of epithelial cells in pericancerous tissue Carcinomas induced by Yunnan tin mine dust in the animal experiment underwent inflammation fibroplasia hyperplasia dysplasia and carcinogenesis of epithelial cells A correlated and synergistic relationship was observed between bronchial epithelial cell transformation and fibroblast activation in vitro induced by mine dust Fibroblast hyperplasia and activation are important factors that promote the transformation and carcinogenesis of epithelial cells Our findings suggested that pulmonary fibrosis may increase the risk and promote the occurrence of lung cancer which can lead to lung fiber hyperplasia

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