Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Front Med

Search In Journal Title:

Abbravation: Frontiers of Medicine

Search In Journal Abbravation:

Publisher

Higher Education Press

Search In Publisher:

DOI

10.1002/jcp.1030550209

Search In DOI:

ISSN

2095-0225

Search In ISSN:
Search In Title Of Papers:

Protein phosphatase magnesiumdependent 1δ is a no

Authors: Zhi Xu Chunxiang Cao Haiyan Xia Shujing Shi Lingzhi Hong Xiaowei Wei Dongying Gu Jianmin Bian Zijun Liu Wenbin Huang Yixin Zhang Song He Nikki PuiYue Lee Jinfei Chen
Publish Date: 2016/01/25
Volume: 10, Issue: 1, Pages: 52-60
PDF Link

Abstract

Hepatocellular carcinoma HCC is a lethal liver malignancy worldwide In this study we reported that protein phosphatase magnesiumdependent 1δ PPM1D was highly expressed in the majority of HCC cases approximately 59 and significantly associated with high serum αfetoprotein AFP level P = 0044 Kaplan Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCCspecific overall survival HR 2799 95 CI 1346–5818 P = 0006 Overexpressing PPM1D promoted cell viability and invasion whereas RNA interferencemediated knockdown of PPM1D inhibited proliferation invasion and migration of cultured HCC cells In addition PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo Overall results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Progress and perspectives of neural tissue engineering
  2. iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic biomarker of colorectal cancer
  3. MSI/LOH and extron expression of the FHIT gene in gastric carcinoma
  4. Generation and repair of AID-initiated DNA lesions in B lymphocytes
  5. Can intravesical bacillus Calmette-Guérin reduce recurrence in patients with non-muscle invasive bladder cancer? An update and cumulative meta-analysis
  6. Tissue engineering of cartilage, tendon and bone
  7. Simultaneous acquisition of CT angiography and whole brain CT perfusion images by using multiphase dynamic helical scan on 16 MDCT
  8. Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia
  9. Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity
  10. Pathogenesis sequences in Gejiu miners with lung cancer: an introduction
  11. Caveolin proteins: a molecular insight into disease
  12. Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2 in breast cancer
  13. Mesenchymal stem cells hold promise for regenerative medicine
  14. Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters
  15. Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice
  16. Influence of survivin-targeted siRNA on the biological features of colorectal carcinoma cells
Search Result: