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Title of Journal: J Food Sci Technol

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Abbravation: Journal of Food Science and Technology

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Springer India

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DOI

10.1007/0-387-31821-6_71

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ISSN

0975-8402

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Antihypercholesterolemic and antioxidant effect of

Authors: Piyush Dikshit Mool Kumar Tyagi Kirtikar Shukla Jasvindar K Gambhir Rimi Shukla
Publish Date: 2015/11/12
Volume: 53, Issue: 3, Pages: 1690-1697
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Abstract

Musa sapientum Linn English ‘Banana’ family Musaceae is a plant with nutritive as well as medicinal value Antihypercholesterolemic and antioxidant effect of methanolic extract of stem of this plant was investigated in hypercholesterolemic rats Rats were made hypercholesterolemic by feeding cholesterol 100 mg/kg/day suspended in soya oil Treatment groups received extract at a dose of 10 20 and 40 mg/kg/day in addition to cholesterol orally once daily Fasting blood samples were collected before and after 6 weeks treatment Animals were sacrificed and liver stored at 80 °C Total cholesterol HDLcholesterol and triacylglycerol were estimated in blood Malondialdehyde reduced glutathione superoxide dismutase and catalase were measured in blood and liver Total lipids HMG CoA redutase and lipoprotein lipase were investigated in liver Most effective dose was found to be 20 mg/kg/day Rise in total cholesterol LDL + VLDLcholesterol and triacylglycerol in animals receiving only cholesterol was 179  417  and 74  respectively while in animals receiving 20 mg/kg dose rise in these parameters was restricted to 40  106  and 24  HDLcholesterol decreased by 12  in extract treated group while it decreased to 36  in untreated hypercholesterolemic rats Malonaldialdehyde marker of lipid peroxidation decreased while reduced glutathione and enzymes superoxide dismutase and catalase increased significantly in blood and liver p  001 Total lipids in liver decreased and enzymes of lipid metabolism viz HMG CoA redutase and lipoprotein lipase were restored to near normal Gas chromatography mass spectroscopy indicated high content of sterols in extract Study demonstrated that methanol extract of stem of Musa sapientum has significant antihypercholesterolemic and antioxidant effects

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