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Title of Journal: Journal of Pharmacokinetics and Biopharmaceutics

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Abbravation: Journal of Pharmacokinetics and Biopharmaceutics

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Kluwer Academic Publishers-Plenum Publishers

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10.1016/0093-934x(89)90018-7

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0090-466X

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Modeling of drug response in individual subjects

Authors: Andrew W Kelman Brian Whiting
Publish Date: 1980/04/01
Volume: 8, Issue: 2, Pages: 115-130
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Abstract

Pharmacokinetic and drug response data from individual subjects are analyzed empirically by two different mathematical techniques The drugs involved are the antiarrhythmic agent disopyramide whose kinetics can be described by a twocompartment model and two cardiac glycosides digoxin and βmethyl digoxin for which threecompartment models are appropriate The first analytical approach uses multiple linear regression to describe response in terms of the amount of drug in several kinetic compartments The second approach describes response in terms of the drug concentration in an “effect” compartment Both approaches describe the data equally well and require the same number of parameters for model specification

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  2. Quinidine pharmacokinetics in man: Choice of a disposition model and absolute bioavailability studies
  3. Effect of plasma protein and tissue binding on the time course of drug concentration in plasma
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  5. Linear pharmacokinetic models: Geometric construction to determine transfer and elimination rate constants
  6. Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model
  7. Pharmacokinetics of piroxicam, a new nonsteroidal anti-inflammatory agent, under fasting and postprandial states in man
  8. Pharmacokinetics and bioavailability of intravenous, oral, and rectal nitrazepam in humans
  9. Application of optimal sampling theory to the determination of metacycline pharmacokinetic parameters: Effect of model misspecification
  10. Estimation of drug binding parameters
  11. Relationship between plasma or serum drug concentration and amount of drug in the body at steady state upon multiple dosing
  12. Pharmacokinetics of teicoplanin in man after intravenous administration
  13. Theoretical considerations in the calculation of bioavailability of drugs exhibiting Michaelis-Menten elimination kinetics
  14. Mathematical model for in vivo pharmacodynamics integrating fluctuation of the response: Application to the prolactin suppressant effect of the dopaminomimetic drug DCN 203–922
  15. Mathematical model for in vivo pharmacodynamics integrating fluctuation of the response: Application to the prolactin suppressant effect of the dopaminomimetic drug DCN 203–922
  16. Simulation for population analysis of Michaelis-Menten elimination kinetics
  17. Pharmacodynamic modeling of the in vitro vasodilating effects of organic mononitrates
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