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Title of Journal: Journal of Pharmacokinetics and Biopharmaceutics

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Abbravation: Journal of Pharmacokinetics and Biopharmaceutics

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Kluwer Academic Publishers-Plenum Publishers

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DOI

10.1007/978-3-319-46913-3_8

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0090-466X

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Estimation of drug binding parameters

Authors: Richard H Luecke Walter D Wosilait
Publish Date: 1986/02/01
Volume: 14, Issue: 1, Pages: 65-78
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Abstract

Many methods have been suggested and tested to estimate the association constants and binding capabilities of ligandmacromolecule interactions from experimental data This problem is a subset of the general problem of parameter estimation for nonlinear algebraic models where both the independent and dependent variables are subject to measurement error It is often difficult to anticipate the effect on the parameter estimates that is caused by error in the primary measurements In this work a computer algorithm is described which finds the maximum likelihood estimate for the true values of the parameters and also estimates for the values of the measurements It is applied to experimental binding data in two examples for fitting the association constants and binding capacities

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Other Papers In This Journal:
  1. Influence of plasma protein binding kinetics on hepatic clearance assessed from a “tube” model and a “well-stirred” model
  2. Quinidine pharmacokinetics in man: Choice of a disposition model and absolute bioavailability studies
  3. Effect of plasma protein and tissue binding on the time course of drug concentration in plasma
  4. A nonlinear mixed-effects pharmacokinetic model comparing two formulations of cyclosporine in stable renal transplant patients
  5. Linear pharmacokinetic models: Geometric construction to determine transfer and elimination rate constants
  6. Modeling of drug response in individual subjects
  7. Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model
  8. Pharmacokinetics of piroxicam, a new nonsteroidal anti-inflammatory agent, under fasting and postprandial states in man
  9. Pharmacokinetics and bioavailability of intravenous, oral, and rectal nitrazepam in humans
  10. Application of optimal sampling theory to the determination of metacycline pharmacokinetic parameters: Effect of model misspecification
  11. Relationship between plasma or serum drug concentration and amount of drug in the body at steady state upon multiple dosing
  12. Pharmacokinetics of teicoplanin in man after intravenous administration
  13. Theoretical considerations in the calculation of bioavailability of drugs exhibiting Michaelis-Menten elimination kinetics
  14. Mathematical model for in vivo pharmacodynamics integrating fluctuation of the response: Application to the prolactin suppressant effect of the dopaminomimetic drug DCN 203–922
  15. Mathematical model for in vivo pharmacodynamics integrating fluctuation of the response: Application to the prolactin suppressant effect of the dopaminomimetic drug DCN 203–922
  16. Simulation for population analysis of Michaelis-Menten elimination kinetics
  17. Pharmacodynamic modeling of the in vitro vasodilating effects of organic mononitrates
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