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Title of Journal: Journal of Pharmacokinetics and Biopharmaceutics

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Abbravation: Journal of Pharmacokinetics and Biopharmaceutics

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Kluwer Academic Publishers-Plenum Publishers

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10.1016/0301-4215(91)90101-s

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0090-466X

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Relationship between plasma or serum drug concentr

Authors: Donald Perrier Milo Gibaldi
Publish Date: 2015/07/17
Volume: 1, Issue: 1, Pages: 17-22
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Abstract

The average amount of drug in the body at steady state bar Xupon repetitive dosing in a twocompartment open system is related to the average steadystate plasma level bar Cby the apparent volume of distribution at steady state Vssrather than by Vβthe apparent volume of distribution at pseudodistribution equilibrium despite the fact thatbar Cis directly proportional to 1/VβMultiplication ofbar C by ddot V beta results in an overestimate ofbar Xthe magnitude of which depends on the distribution and elimination parameters of the drug The significance and utility of the volume parameters Vβand Vssemployed in multicompartment systems are considered

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  10. Application of optimal sampling theory to the determination of metacycline pharmacokinetic parameters: Effect of model misspecification
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  12. Pharmacokinetics of teicoplanin in man after intravenous administration
  13. Theoretical considerations in the calculation of bioavailability of drugs exhibiting Michaelis-Menten elimination kinetics
  14. Mathematical model for in vivo pharmacodynamics integrating fluctuation of the response: Application to the prolactin suppressant effect of the dopaminomimetic drug DCN 203–922
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  16. Simulation for population analysis of Michaelis-Menten elimination kinetics
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