Authors: Takashi Ishizaki Takeo Nomura Tohru Abe
Publish Date: 2015/07/17
Volume: 7, Issue: 4, Pages: 369-381
Abstract
The kinetic disposition of piroxicam under evaluation in man as a new antiinflammatory drug was studied in human volunteers given a single oral dose after both overnight fasting and food Total absorption was uninfluenced by food intake although the data indicate that food causes some delay in attainment of peak serum levels The halflife of drug in plasma in the fasting subjects 375±24hr was similar in both the fasting state and after food suggesting that oncedaily dosing may be appropriate for maintaining therapeutic plasma levels Mean pharmacokinetic parameters for both studies in the fasting state and after meals are volume of distribution divided by availability 0140 or 0136 liter/kg total plasma clearance divided by availability 268 or 312 ml/hr/kg Approximately 10 of a single dose of piroxicam was eliminated in the urine within 8 days after oral drug administration Renal clearance of the drug 028±010 ml/hr/kg was 104 or less of plasma clearance suggesting that piroxicam is extensively metabolized In this study one subject showed a reduction in white blood count on the sixteenth day after a 60mg dose however hematology values evaluated in both intraand intersubject comparisons did not show any other differences in the present study
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