Pharmacokinetics of teicoplanin in man after intra

Authors: Gian Luigi Traina Maurizio Bonati

Publish Date: 1984/04/01

Volume: 12, Issue: 2, Pages: 119-128

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Abstract

The pharmacokinetics of teicoplanin a new glycopeptide antibiotic active against grampositive aerobic and anaerobic bacteria was studied in adult male volunteers given 2 and 3 mg/ kg doses by a constantrate 05hr infusion Serum and urine samples were collected up to 96 hr Mean peak serum levels after the two doses were 157 and 224 μg/ml Postinfusion serum teicoplanin levels showed triexponential decay A threecompartment body model gave close values for pharmacokinetic parameters after the two doses The mean halflife of the λ1 phase was 203 min that of the λ2 phase was 29 hr and the halflife of the estimated λ3 phase was 405 hr in good agreement with that of the λZ phase 459 hr calculated from the last urine data The mean volume of distribution of the central compartment was 009 liter/kg and the steadystate volume of distribution using noncompartmental analysis was 084 liter/kg Total clearance averaged 1605 ml/hr/kg with renal clearance arbout half this 951 ml/hr/kg calculated by two different methods The average total recovery of active teicoplanin in urine over 4 days was 52 suggesting that both renal and nonrenal mechanisms are involved in elimination of the drug The concentrations of teicoplanin in serum and urine exceeded the MIC ranging from 002 to 2 μg/ml on many pathogenic organisms for at least 1 day after administration

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