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Title of Journal: Exp Brain Res

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Abbravation: Experimental Brain Research

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Springer-Verlag

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DOI

10.1002/chin.200011214

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1432-1106

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The role of connexins in the differentiation of NT

Authors: R Shamekh D F Cameron A E Willing S Saporta
Publish Date: 2005/11/19
Volume: 170, Issue: 2, Pages: 277-284
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Abstract

Neural transplantation is developing as a successful treatment for neurodegenerative diseases such as Parkinson’s disease The human Ntera2/D1 NT2 cell line is an attractive alternative to the use of human fetal neurons as a cell source for transplantation We have explored combining NT2 cells as a neuronal source and Sertoli cells which may act as a graft facilitator to enhance neuronal survival and differentiation and ameliorate the host immune response into a tissue construct for use in cell replacement therapy for neurodegenerative disease This SertoliNT2aggregated cell SNAC tissue construct is formed in the high aspect ratio vessel HARV bioreactor NT2 cells differentiate to dopaminergic NT2N neurons within the SNAC tissue construct without retinoic acid We report here that the gap junction protein connexin 43 is decreased among differentiated NT2N neurons Inhibition of connexin 43 with 18β glycyrrhetinic acid and carbenoxolone a glycyrrhetinic acid derivative during formation of the SNAC tissue constructs disrupts the differentiation of NT2 cells Therefore connexin 43 is important in the differentiation of NT2 cells in the SNAC tissue construct

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