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Title of Journal: Acta Neurochir Wien

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Abbravation: Acta Neurochirurgica

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Springer-Verlag

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DOI

10.1002/chin.200746008

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0942-0940

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Intrasellar germinoma treated with lowdose radiat

Authors: C S Li
Publish Date: 2006/05/04
Volume: 148, Issue: 7, Pages: 795-799
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Abstract

A radiation dose lower than what had previously been recommended was given to a case of intrasellar germinoma in a 17yearold patient who suffered from migrainelike headache for 2 years amenorrhoea for 3 months and a bodyweight loss of 10 kg over 4 months Baseline assessment of pituitary hormone reserve was within the lower limits of the normal range except for an elevated serum prolactin level PRL Magnetic resonance imaging MRI showed an abnormal slightly enhanced mass in the pituitary fossa extending along the pituitary stalk and to the hypothalamus Transsphenoidal removal of the intrasellar part of the tumour was performed and microscopic sections of the surgical specimens revealed a pure germinoma Adjunctive radiation therapy RT was given 3 weeks after surgery A total dose of only 27 Gy was delivered to this patient The patient’s menstrual cycles resumed in 4 months Repeated MRI followup showed no recurrence of the tumour

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