Authors: Rabih Aboukais Fahed Zairi Marc Baroncini NicolasXavier Bonne Stéphane Schapira Christophe Vincent JeanPaul Lejeune
Publish Date: 2013/04/05
Volume: 155, Issue: 6, Pages: 997-1001
Abstract
In spite of the few clinical studies regarding the occurrence of intracranial meningiomas their prognosis in neurofibromatosis type 2 NF2 has not been accurately assessed and their management remains controversial This study aims to compare NF2 patients with intracranial meningiomas to those without and consequently to identify prognostic factors in attempt to improve the management of these tumorsThis retrospective study includes a total of 80 NF2 patients followed at Lille Hospital Center between 1987 and 2011 The diagnosis of NF2 was confirmed either because the patient met the Manchester criteria or by the presence of genetic mutation Clinical radiological and genetic data were retrospectively recorded and analyzed Patients underwent annual cranial and spinal MRI Both location and size of each tumor were reportedThe mean followup period was 88 years range 1–24 years SD ±08 and the mean age at diagnosis was 272 years range 6–73 years SD ±17 Among all patients 34 harbored intracranial meningiomas Patients with intracranial meningiomas had a higher number of intracranial schwannomas spinal tumors and cutaneous tumors p 005 They underwent more surgical procedures p 0012 Twenty five intracranial meningiomas were surgically removed in 17 patients The decision to perform surgery was taken in 10 cases for symptomatic tumors and in 15 cases for growing asymptomatic tumors determined by radiology The histological analysis found a high rate of fibroblastic transitional or grade 2 meningiomas preferentially located at the cerebri falxIntracranial meningiomas are common in NF2 They are associated with poor prognosis factors Clinical and radiological monitoring could lead to early treatment of these tumors both when clinical symptoms are present and in case of proven radiological evolution and thus trying to maintain a favorable functional prognosis for as long as possibleThe manuscript is concise clearlywritten and the final message is convincingly addressed When comparing NF2 patients with intracranial meningiomas to those without intracranial meningiomas are associated with poor prognosis factors The main weakness of this paper is the limited number of patients with meningiomas in the overall case material
Keywords: