Authors: Anne Laure Bernat Kenichi Oyama Selma Hamdi Emmanuel Mandonnet Dominique Vexiau Marc Pocard Bernard George Sebastien Froelich
Publish Date: 2015/08/12
Volume: 157, Issue: 10, Pages: 1741-1746
Abstract
Since 2010 all patients referred to our clinic for a suspicion of meningioma were questioned specifically about exogenous sex hormone intake and more specifically about CA intake Twelve patients harboring one or multiple meningiomas and treated with CA were identified CA was stopped in all cases Tumor volumes and diameters were measured on serial MRIs and compared to the last MRI before CA withdrawalTen patients with multiple tumors had been taking the drug for a longer period of time mean of 204 years than the two patients with one tumor 10 years Two patients with multiple tumors underwent surgery because of rapidly decreased visual acuity at the time of diagnosis Discontinuation of CA led to tumor shrinkage in 11 patients and a stop in tumor growth in one mean tumor volume reduction was around 10 cm3/year range 000 76 There was no regrowth during a mean followup period of 12 months range 5–35For patients diagnosed with a meningioma and treated with CA medication withdrawal followed by observation should be the first line of treatment Care should be taken with longterm use of high doses of CA and serial brain MRIs should be considered after several years of CAAll authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest such as honoraria educational grants participation in speakers’ bureaus membership employment consultancies stock ownership or other equity interest and expert testimony or patentlicensing arrangements or nonfinancial interest such as personal or professional relationships affiliations knowledge or beliefs in the subject matter or materials discussed in this manuscript
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