Authors: Soi Mei Chye You Cheng Hseu ShihHsiung Liang ChinHui Chen Ssu Ching Chen
Publish Date: 2007/12/06
Volume: 80, Issue: 1, Pages: 58-62
Abstract
ParaPhenylenediamine PPD the main aromatic amines used in the hair dye formation and its four derivatives 2chloropphenylenediamine 4chloroophenylenediamine 2nitropphenylenediamine and 4nitroophenylenediamine were examined for their potential to produce single strand DNA breaks in human lymphocytes using the alkaline comet assay Results revealed that all the tested chemicals within the range of doses from 100 μM to 500 μM showed the genotoxicity in a dosedependent manner after the incubation of lymphocytes with these chemicals for 2 h In this study we first reported that PPD and its four derivatives can elicit the type of single strand breaks in human lymphocytes
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