Authors: Liwei Sun Xia Lin Rong Jin Tao Peng Zuhua Peng Zhengwei Fu
Publish Date: 2014/05/22
Volume: 93, Issue: 2, Pages: 222-227
Abstract
The toxic effects of bisphenol A BPA in aquatic organisms have attracted global attention However few studies have investigated its effects at the gene transcription level In this study we measured the transcriptional response of a set of genes associated with the hypothalamic–pituitary–gonadal axis following BPA exposure during the early life stage of Japanese medaka Transcription of vitellogenin genes was induced in both sexes indicating estrogenic disruption However changes in transcription of the steroid hormone receptor gene and steroidogenesisregulating genes suggest that BPA also acts as an androgen receptor antagonist BPA exposure also decreased the hatchability of medaka embryos and increased the growth of female larvae These pronounced genderspecific effects observed in this study demonstrate that it is important to identify the sex of fish in the early life stage
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