Study on a possible effect of four longevity candi

Authors: Rosa Maria Corbo Laura Ulizzi Laura Piombo Renato Scacchi

Publish Date: 2008/04/26

Volume: 9, Issue: 5, Pages: 317-323

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Abstract

The present study investigated for a possible effect on fertility of four longevity candidate genes ACE PON1 PPARγ APOE in order to determine whether they have a pleiotropic action at different life ages The study population was 151 healthy unrelated subjects Only PPARγ and APOE showed an effect on fertility The PPARγ Pro/Ala genotype which had showed an association with longevity only in men was found associated only in men with having produced more children 61 ± 33 than the Pro/Pro genotype 33 ± 19 P = 0001 APOE2 allele which has been consistently associated with longevity was confirmed to be associated with the lowest fertility P = 003 The logistic regression analysis indicated that APOE and PPARγ polymorphisms may be considered independent determinants of reproductive efficiency These data suggest that the APOE2 allele follows the model of antagonist pleiotropy while the PPARγ Pro/Ala genotype seems to exert beneficial effects both early in life and in advanced age in a genderspecific way

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